I have a 2002 f150 4.6 that was sitting for few years because of rough idle and misfire I changed intake gasket all plugs all coils and ran fine all day I filled tank up and drove good then when tank got down to 1/4 tank started running rough and losing all power then it would die I would restart and would run good for bout 5 mins then same problems I filled tank back up and added a bottle of seafoam to fuel tank while fueling now has slight miss when taking off from a stop and when I start the engine it take longer then normal to start any help is appreciated

 

Change the fuel filter and drain the gas tank, put fresh gas in. DO NOT USE Seafoam! The only additive you should use is Techron or something else that has PEA. Seafoam is rough on catalytic converters.

If the Techron doesn't help, I'd consider getting the injectors bench cleaned and tested - or rebuild them.

 

I got a new filter I will install it in morning and see how it runs