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my first truck was a reg cab 6 cyl. I put a 4in fabtech susp. and 285/70/16 tires on. I got about 14 mpg. Mine was a auto trans though with 3:55 Non LS
I know you didn't ask, but mine is stock with 255/70-16 and the only mods are a K&N dropin and a 2.5" SISO VForce, and I average about 18. It gets about 16 in the city and 19-22 on the highway.