22's in the back and 20's in the front.

 

Little hard to answer the question when we don't have jack for info on the truck and tires. If you keep the overall tire diameter the same then no there won't be any problems. An example is if you compare a 265/75/16 to a 265/70/17. Both tires have the same diameter, but one fits a 17 and the other a 16. The truck wouldn't know the difference between them. If you plan to run 2 different tire diameters and you have a 4x4 then no it won't work.

 

sorry pwr. i meant for looks

 

it depends on if your truck is lowered and if so by how much. mine has a 3/4 drop on it and i can put 20's on it no prob but not a chance w/ 22's. so like i said it depends