Price?
If you plan on going bigger in the future, like 35s or 37s, then you might want to look into 4.56s. They will work better if you ever move up in tire size. But, if you don't have any desire to go bigger then 4.10s will work good and you are probably looking at around $1500 installed.
If you have 2wd and a 5.4, 4.10's should be fine unless you are going for an extreme tire size.
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I have 305/50R20 now, on 3.55LS.. I want to go up to 33x12.5 when I get new tires, but I don't want to hurt my gas mileage even more, or hurt my tranny, but if I'm going to 33s I thought I might as well lift a little more and get 35s
I do a decent amount of driving highway, etc are 4.10s okay for that?





