Is there a way to determine if a vehicle ('11 350 van) has keyless entry
Keys were lost and boss had locksmith make key. Now I have van and 2 extra fobs I would like to program one if it's possible

 

You could look up the programming method for that particular vehicle (which should be in the forums somewhere) and see it they work then. If not, you can always call a local dealer with the last 8 numbers of the VIN and they will be able to tell you. Hope this helps.