What size tire should I run?
 

I have a 2000 F-150 2wd and I am going to put a 3.5 inch spindle lift in the front along with a 2 inch coil spring spacer and a 4 inch block in the back. I am trying to figure out what size tire I should run with that lift? Any help is appreciated

Depend on the wheel you use. Personally, I'd go with 33's on an 8 inch wide wheel with 4.5 inches of backspacing.