2010 f150 TPMS problem
 

I have a 2010 XLT F150 crew cab 4.6L. The problem I am having is I am getting TPMS fault on the dash. The sensors in the tires have been replace and have been trained/reset, but the TPMS light keep coming on. I took my truck to a tire shop and they reprogram the sensors with their programmer and still the light come on. Also when the TPMS light comes on the AC compressor stop running. I can clear the TPMS light for a few minutes by pressing the mileage reset a bunch of times. then the AC compressor comes on when the TPMS light/message goes away. This make me feel that the TPMS module is going out and need to be replace. Why it interferes with the AC I don't know maybe it is sending a weird signal causing other modules to act up.
Would it be wise to replace the TPMS module and is it plug and play?
Where is the TPMS module located?

It might be a bad battery in one of the sensors... People forget they have batteries.

Also, it may work in a warm shop, but the battery might not have enough voltage when you are outside.

Just a suggestion.

I am having the same issue minus the AC problem. I get the error only on long drives, though.

If the TPMS sensors are original, more than likely they're near the end of their life (typically 8-10 years).

Another consideration ...

FWIW I've only had to replace one of the original sensors in my 2010 FX-4 (built in late 2009). But it you're changed tires multiple time, then that might affect the life of the sensors. I'm still on my 2nd set of tires.

As far as I know, except for the five sensors in the wheels, the TPMS is entirely in the BCM electronics. The BCM handles a majority of the electronic systems in the truck so it would be major job to replace it. Several years ago, there was a post I think on this forum, that showed a BCM and they pointed out the area of the circuit that performed the TPMS. The poster in this old thread also had problems with his AC system and TPMS interacting, link I don't think that they are intended to interact but I believe that both circuits are located on the BCM and close enough together that a failure in one circuit may also affect the other.

But I would take Manual's advice and replace the truck battery first. Goofy batteries have been known to cause a lot of bizzarre problems.