This link both measures difference in aero drag and shows the smoke path over the various configurations on a Dodge truck.
Dodge Truck aero drag changes
On my truck I notice a very slight difference in mileage with the tonneau cover on, but I don't get in a lot of highway miles.
Unless you're looking for a free mileage upgrade, I would suggest either underdrive pulleys, electric fans, or ignition upgrades. If you drive a lot of highway miles the tonneau or hard cover might pay off a little better than in my case.