It's BEST to get a HU that has pre-amp outputs. That will get you the cleanest, unamplified (by HU) signal to the exteral amp. But do you HAVE TO have pre-outs on a HU in order to use an amp? No. There's always the option of using line output converters (hi/low converters). Those take the speaker-level output wires, and convert them to low-level (RCA) outputs, that you can then run to your amp. The draw-back is that the signal isn't as clean if you use a hi-low converter. Main reason is because the speaker-level outputs from HU's are already amplified from the HU's interal amp. Amplifing an amplified signal creates unwanted noise... But many people do it, and many are happy with it. It all depends on what level of sound quality you're looking for.
PS, if you do decide to go with a line output converter, do yourself a favor and get the one from David Navone (
www.davidnavone.com). He makes, hands-down, the best LOC in the industry.